Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications

Atherosclerosis (AS), the underlying cause of most cardiovascular events, is one common causes human morbidity and mortality worldwide due to lack an efficient strategy for targeted therapy. In this work, we aimed develop ideal biomimetic nanoparticle AS Methods: Based on macrophage homing into atherosclerotic lesions cell membrane coating nanotechnology, nanoparticles (MM/RAPNPs) were fabricated with a (MM) surface rapamycin-loaded poly (lactic-co-glycolic acid) copolymer (PLGA) (RAPNPs). Subsequently, physical properties MM/RAPNPs characterized. The biocompatibility biological functions determined in vitro. Finally, mouse models, targeting characteristics, therapeutic efficacy safety examined. Results: advanced demonstrated good biocompatibility. Due MM coating, effectively inhibited phagocytosis by macrophages activated endothelial cells addition, MM-coated accumulated vivo. After 4-week treatment program, shown significantly delay progression AS. Furthermore, displayed favorable performance after long-term administration. Conclusion: These results demonstrate that could efficiently safely inhibit may be potential drug delivery systems safe effective anti-AS applications.